The role of the lymphatic system in inflammatory-erosive arthritis. (February 2015)

• Record Type: Journal Article
• Authors: Bouta, Echoe M.; Li, Jie; Ju, Yawen; Brown, Edward B.; Ritchlin, Christopher T.; Xing, Lianping; Schwarz, Edward M.
• Is Part Of: Seminars in cell & developmental biology. Volume 38(2015)
• Page Start: 90
• Page End: 97
• Publication Date: 2015-02
• Subjects: ACPA anti-citrillunated protein antibodies -- B-in B cells in inflamed nodes -- BCDT B cell depletion therapy -- CE-MRI contrast enhanced magnetic resonance imaging -- eNOS endothelial nitric oxide synthase -- FITC-BSA fluorescein isothiocyanate labeled bovine serum albumin -- Gd-DTPA gadolinium-diethylenetriamine pentaacetic acid -- IMID immune-mediated inflammatory disorder -- iNOS inducible nitric oxide synthase -- LPP lymphatic pumping pressure -- LN lymph node -- LNCE lymph node contrast enhancement -- LNCap lymph node capacity -- LNP lymph node pressure -- MP-FRAP multiphoton fluorescence after photobleaching -- NIR-ICG near infrared-indocyanine green -- NPDV normalized power Doppler volume -- NO nitric oxide -- OCPs osteoclast precursors -- PLN popliteal lymph node -- PD-US power Doppler ultrasound -- RA rheumatoid arthritis -- RF rheumatoid factor -- SV synovial volume -- TNF-Tg tumor necrosis factor alpha transgenic -- US ultrasound -- VEGF-C vascular endothelial growth factor c -- VEGFR3 vascular endothelial growth factor receptor 3 -- WT wild-type; Rheumatoid arthritis -- Lymph node -- Flare -- Lymphatic vessel; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2015.01.001
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares, which causes swelling, pain, and irreversible connective tissue damage. Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it "expands" in size and contrast enhancement during a prolonged asymptomatic phase, prior to when it "collapses" with accelerated synovitis and joint erosion. This PLN collapse is associated with adjacent knee flare, decreases in PLN volume and contrast enhancement, lymphatic pulse and pumping pressure, and an increase in PLN pressure. Currently, it is known that PLN collapse is accompanied by a translocation of B cells from the follicles to the sinuses, effectively clogging the lymphatic sinuses of the PLN, and that B cell depletion therapy ameliorates arthritic flare by eliminating these B cells and restoring passive lymphatic flow from inflamed joints. Here we review the technological advances that have launched this area of research, describe future directions to help elucidate the potential mechanism of PLN collapse, and speculate on clinical translation towards new diagnostics and therapies for RA.