Cover Feature: Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics (ChemMedChem 8/2018). (23rd April 2018)

• Record Type: Journal Article
• Authors: Koppermann, Stefan; Cui, Zheng; Fischer, Patrick D.; Wang, Xiachang; Ludwig, Jannine; Thorson, Jon S.; Van Lanen, Steven G.; Ducho, Christian
• Is Part Of: ChemMedChem. Volume 13:Number 8(2018)
• Page Start: 763
• Page End: 763
• Publication Date: 2018-04-23
• Subjects: activity assays -- antibiotics -- natural products -- nucleosides -- structure–activity relationships; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201800227
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Cover Feature shows a naturally occurring muraymycin nucleoside antibiotic blocking the reaction mediated by the bacterial membrane protein MraY. MraY catalyzes the formation of the membrane‐bound intermediate lipid I and therefore a key step in peptidoglycan biosynthesis. In the corresponding paper by Koppermann, Ducho et al., a range of muraymycin natural products were re‐investigated for their interaction with MraY, revealing unprecedented details on the molecular level based on a combination of in vitro assays and in silico modelling. These results will pave the way for the development of muraymycin analogues with optimized properties as antibacterial drug candidates. More information can be found in the Communication by Christian Ducho et al. onpage 779 in Issue 8, 2018 (DOI:10.1002/cmdc.201700793 ).