High control rates of proton‐ and carbon‐ion–beam treatment with intensity‐modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center. Issue 9 (22nd February 2018)

• Record Type: Journal Article
• Authors: Mattke, Matthias; Vogt, Kira; Bougatf, Nina; Welzel, Thomas; Oelmann‐Avendano, Jan; Hauswald, Henrik; Jensen, Alexandra; Ellerbrock, Malte; Jäkel, Oliver; Haberer, Thomas; Herfarth, Klaus; Debus, Jürgen; Uhl, Matthias
• Is Part Of: Cancer. Volume 124:Issue 9(2018)
• Page Start: 2036
• Page End: 2044
• Publication Date: 2018-02-22
• Subjects: carbon ion -- chondrosarcoma -- heavy ion -- proton -- radiotherapy -- skull base; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.31298
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : BACKGROUND: The current study compares the results of irradiation with protons and irradiation with carbon ions via a raster scan technique in patients with G1 and G2 skull base chondrosarcomas. METHODS: Between 2009 and 2014, a total of 101 patients (40 men and 61 women) with a median age of 44 years (range, 19‐77 years) were irradiated with carbon ions (79 patients) or protons (22 patients) via a raster scan technique at the Heidelberg Ion Beam Therapy Center. The median total dose was 60 Gy (relative biological effectiveness [RBE]) at 3 Gy per fraction for carbon ions and 70 Gy (RBE) at 2 Gy per fraction for protons. The median boost planning target volume was 38 cm 3 (range, 8‐133 cm 3 ). Overall survival (OS) and local control (LC) were evaluated with the Kaplan‐Meier method. RESULTS: The median follow‐up period was 40 months (range, 0.8‐78.1 months). At the start of the irradiation, all patients had residual macroscopic tumors. Five patients (5%) developed a local recurrence during the follow‐up. The 1‐, 2‐, and 4‐year LC rates were 100%, 100%, and 100%, respectively, for protons and 98.6%, 97.2%, and 90.5%, respectively, for carbon ions. The OS rates during the same periods of time were 100%, 100%, and 100%, respectively, for protons and 100%, 98.5%, and 92.9%, respectively, for carbon ions. An age ≤ 44 years was associated with a trend for a better outcome. No toxicity worse than Common Toxicity Criteria grade 3 was observed after treatment. CONCLUSIONS: No significant difference between carbon ions and protons in the therapy of skull base chondrosarcoma could be detected in these initial retrospective results. Cancer 2018;124:2036‐44 . © 2018 American Cancer Society . Abstract : This is the first study to retrospectively compare the results of proton‐ and carbon‐ion treatments for skull base chondrosarcomas at a single center. There is no significant difference between protons and carbon ions.