Antibody response to hepatitis B vaccine in HIV‐exposed infants in Malawi and correlation with HBV infection acquisition. Issue 6 (26th February 2018)

• Record Type: Journal Article
• Authors: Mancinelli, Sandro; Pirillo, Maria F.; Liotta, Giuseppe; Andreotti, Mauro; Mphwere, Robert; Amici, Roberta; Marazzi, Maria C.; Vella, Stefano; Palombi, Leonardo; Giuliano, Marina
• Is Part Of: Journal of medical virology. Volume 90:Issue 6(2018)
• Page Start: 1172
• Page End: 1176
• Publication Date: 2018-02-26
• Subjects: HBV -- HBV vaccine -- HIV‐exposed infants -- sub‐Saharan Africa; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25049
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : The aim of this study was to assess the immune response to HBV vaccine in HIV‐exposed infants and to correlate it to HBV infection acquisition. Protective anti‐HBs levels (>10 mIU/mL) were found in 54/58 (93.2%) infants at 6 months, 126/144 (87.5%) at 12 months and 141/176 (80.1%) children at 24 months. HBV infection (seven children were HBsAg + at Month 24) occurred also in the presence of levels above 10 mIU/mL. Our findings indicate limited impact of HIV exposure on anti‐HBV immune response, but suggest that levels >10 mIU/mL may be required to confer protection in this context.