Complementary Diagnostic Value of Heart Type Fatty Acid-binding Protein in Early Detection of Acute Myocardial Infarction. Issue 1 (March 2018)

• Record Type: Journal Article
• Authors: Sotoudeh Anvari, Maryam; Karimi, Mahsa; Shafiee, Akbar; Boroumand, Mohammadali; Bozorgi, Ali; Sedaghat, Reza; Jalali, Arash
• Is Part Of: Critical pathways in cardiology. Volume 17:Issue 1(2018)
• Publication Date: 2018-03
• Subjects: acute myocardial infarction -- cardiac troponin -- diagnosis -- heart-type fatty acid-binding protein -- sensitivity -- specificity; Cardiology -- Periodicals; Evidence-based medicine -- Periodicals; Medical protocols -- Periodicals; 616.12005
• DOI: 10.1097/HPC.0000000000000107
• Languages: English
• ISSNs: 1535-282X

Abstract

Abstract : Background: Heart-type fatty acid-binding protein (H-FABP) is a novel biomarker for myocardial injury. We compared the use of H-FABP with serum levels of cardiac troponin-T (cTnT) and creatine kinase-MB (CK-MB) in the diagnosis of patients suspicious to acute myocardial infarction (AMI). Methods: From October 2013 to December 2014, 182 consecutive patients suspicious to acute coronary syndrome were enrolled in this study, who presented within the past 6 hours from the onset of symptoms. Venous blood samples were drawn at baseline to measure serum biochemistry, high-sensitive cardiac troponin T (hs-cTNT), creatine kinase-MB, and H-FABP, and the measurements were repeated after 8 hours. The patients were categorized into 3 groups based on the baseline and second measurements of cTnT and general characteristics, and changes of H-FABP levels were then compared between the groups. Sensitivity and specificity of H-FABP in predicting the presence of AMI was calculated. Results: A total of 91 patients had AMI. Changes of H-FABP through time were also significantly different between the AMI and non-AMI patients ( P < 0.001). A cutoff point of 7.15 for H-FABP could predict AMI with a sensitivity of 51.5%, specificity of 96.3%, and diagnostic accuracy of 68.3%. The area under the receiver operating characteristic curve for H-FABP at 8 hours was 79.4% (95% confidence interval: 73.0–85.9; P < 0.001). Positive predictive value and negative predictive value for H-FABP were 85% and 60%, respectively. Conclusions: H-FABP can be used as an additional cardiac biomarker in the diagnosis of AMI.