The impact of different torques for the insertion of immediately loaded implants on the peri-implant levels of angiogenesis- and bone-related markers. Issue 5 (May 2018)

• Record Type: Journal Article
• Authors: Verrastro Neto, A.; Andrade, R.; Corrêa, M.G.; Casarin, R.C.V.; Casati, M.Z.; Pimentel, S.P.; Ribeiro, F.V.; Cirano, F.R.
• Is Part Of: International journal of oral & maxillofacial surgery. Volume 47:Issue 5(2018:May)
• Page Start: 651
• Page End: 657
• Publication Date: 2018-05
• Subjects: torque -- immediate dental implant loading -- bone -- biological markers -- protein array; Mouth -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Dentistry -- Periodicals; Dentistry, Operative; Oral Surgical Procedures; Surgery, Oral; Dentistry; Maxilla -- Surgery; Mouth -- Surgery; Electronic journals; Periodicals; 617.52059
• DOI: 10.1016/j.ijom.2017.11.001
• Languages: English
• ISSNs: 0901-5027

Abstract

Abstract: The aim of this split-mouth, randomized, double-blind, controlled clinical trial was to evaluate the influence of different insertion torque values for dental implants on bone- and angiogenesis-related marker profiles. Eighteen edentulous patients received dental implants and fixed complete-arch mandibular prostheses. The implants ( n = 36) were assigned randomly to two groups: reduced torque ( n = 18), with insertion torque <30 N cm; and conventional torque ( n = 18), with insertion torque ≥30 N cm. Levels of vascular endothelial growth factor (VEGF), placental growth factor, bone morphogenetic protein 9 (BMP-9), periostin, osteoprotegerin (OPG), and tartrate-resistant acid phosphatase (TRAP) in the peri-implant fluid were quantified at 7, 14, 30, and 120 days after implant placement. Inter-group comparisons showed that VEGF and OPG levels were higher in the low-level torque group than in the conventional torque group on days 7 and 30, respectively ( P < 0.05). BMP-9 and periostin levels were higher in the conventional group than in the low-level torque group on day 120, and TRAP was up-regulated around implants inserted with conventional torque when compared to those inserted with lower-level torque at all time points evaluated ( P < 0.05). In conclusion, the use of different levels of torque for implantation of immediately loaded implants significantly influenced the levels of bone- and angiogenesis-related markers during early peri-implant repair.