Effect of Lactococcus lactis subsp. cremoris YRC3780 on birch pollinosis: a randomized, double-blind, placebo-controlled clinical trial. (April 2018)

• Record Type: Journal Article
• Authors: Uchida, Kenji; Motoshima, Hidemasa; Katano, Naoya; Hachimura, Satoshi; Tanaka, Aiko; Nishihira, Jun
• Is Part Of: Journal of functional foods. Volume 43(2018)
• Page Start: 173
• Page End: 179
• Publication Date: 2018-04
• Subjects: Allergy -- Birch pollinosis -- HOKKAIDO -- Lactococcus lactis subsp. cremoris -- Medication score -- Thymus and activation-regulated chemokine (TARC); IFN interferon -- OVA ovalbumin -- QOL quality of life -- TARC thymus and activation-regulated chemokine -- TNF tumor necrosis factor -- YRC3780 Lactococcus lactis subsp. cremoris YRC3780; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.01.030
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Medication scores of YRC3780-treated groups were significantly lower than placebo. In the YRC3780-treated groups, blood levels of TARC were significantly decreased. Consuming of YRC3780 ameliorated the symptoms of birch pollinosis. Abstract: In a randomized, double-blind, placebo-controlled trial, 114 patients with birch pollinosis received Lactococcus lactis subsp. cremoris YRC3780 (YRC3780) powder (n = 28, 29, 28, in each dose group) or a placebo (1 g starch powder, n = 29) daily for 12 weeks during the 2016 pollen season. Patients self-recorded their symptom and medication scores daily, and blood samples were evaluated every 4 weeks throughout the treatment observation periods. Symptom and medication scores during the intake period were grouped into 6 consecutive periods of 2 weeks each, and average values were compared between periods. In the YRC3780-treated groups, medication scores were significantly lower than scores in the placebo group during intake periods 3 ( P < 0.05). In addition, blood levels of thymus- and activation-regulated chemokines (TARC) at 12 weeks were significantly decreased. Consuming at least 10 9 CFU of YRC3780 daily ameliorated the symptoms of birch pollinosis, likely by improving Th1/Th2 balance.