Unloosing the Gordian knot of peroxisome formation. (February 2018)

• Record Type: Journal Article
• Authors: Costello, Joseph L; Schrader, Michael
• Is Part Of: Current opinion in cell biology. Volume 50(2018)
• Page Start: 50
• Page End: 56
• Publication Date: 2018-02
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2018.02.002
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : Peroxisome biogenesis is governed by molecular machineries, which are either unique to peroxisomes or are partially shared with mitochondria. As peroxisomes have important protective functions in the cell, modulation of their number is important for human health and disease. Significant progress has been made towards our understanding of the mechanisms of peroxisome formation, revealing a remarkable plasticity of the peroxisome biogenesis pathway. Here we discuss most recent findings with particular focus on peroxisome formation in mammalian cells.