Atom‐by‐atom engineering of voltage‐gated ion channels: Magnified insights into function and pharmacology. (13th March 2015)

• Record Type: Journal Article
• Authors: Pless, Stephan A.; Kim, Robin Y.; Ahern, Christopher A.; Kurata, Harley T.
• Is Part Of: Journal of physiology. Volume 593:Number 12(2015:Jun.)
• Page Start: 2627
• Page End: 2634
• Publication Date: 2015-03-13
• Subjects: Physiology -- Periodicals; 612.005
• DOI: 10.1113/jphysiol.2014.287714
• Languages: English
• ISSNs: 0022-3751

Abstract

Abstract : Abstract: Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage‐gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.