Desalted Salicornia europaea powder and its active constituent, trans-ferulic acid, exert anti-obesity effects by suppressing adipogenic-related factors. (1st January 2018)

• Record Type: Journal Article
• Authors: Rahman, Md. Mahbubur; Kim, Myung-Jin; Kim, Jin-Hyoung; Kim, Sok-Ho; Go, Hyeon-Kyu; Kweon, Mee-Hyang; Kim, Do-Hyung
• Is Part Of: Pharmaceutical biology. Volume 56:Number 1(2018)
• Page Start: 183
• Page End: 191
• Publication Date: 2018-01-01
• Subjects: Desaltation -- adipogenesis -- 3T3L-1 cells -- abdominal fat mass; Pharmacognosy -- Periodicals; Materia medica, Vegetable -- Periodicals; 615.321
• DOI: 10.1080/13880209.2018.1436073
• Languages: English
• ISSNs: 1388-0209

Abstract

Abstract: Context: Salicornia europaea (Amaranthaceae) (SE) has been shown to reduce obesity, but it remains a problem as a food supplement because of its high salt content (25–35% NaCl). Objectives: This study investigated the anti-obesity effects and mechanism of action of desalted SE powder (DSP). Materials and methods: Sprague–Dawley rats ( n = 50) were divided into a normal control group (NC), a high-fat diet (HFD)-induced obesity control group (HFD), and HFD groups co-administered DSP (250 and 500 mg/kg) or Garcinia cambogia (Clusiaceae) extract (GE, 200 mg/kg, standard control) orally each day for 12 weeks. Results: The body weight was significantly reduced by co-administration of DSP (596.51 ± 19.84 kg, 4.60% and 562.08 ± 9.74 kg, 10.10%, respectively) and GE (576.00 ± 11.29 kg, 7.88%) relative to the HFD group (625.25 ± 14.02 kg) and was accompanied by reduced abdominal fat mass, and serum lipid levels, with no effects on feed intake. To find the underlying mechanism of the anti-obesity effects, trans -ferulic acid (TFA) was identified as the main ingredient and investigated with regard to whether it attenuated adipogenesity in 3T3L-1 cells. DSP-derived TFA suppressed adipocyte differentiation and accumulation of intracellular lipids. TFA also down-regulated the adipogenesis-related gene expression of sterol regulatory element-binding protein 1, peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein-α and fatty acid synthase. Conclusions: These findings suggest that DSP may be considered for use as a food supplement intent of controlling obesity through its antiobesity and antiadipogenic properties.