Aggressive Initial Presentation of HLA-B27 Uveitis in Older Individuals: A Case Series. (3rd April 2018)

• Record Type: Journal Article
• Authors: Ganapathy, Preethi S.; Lowder, Careen Y.; Srivastava, Sunil K.
• Is Part Of: Ocular immunology and inflammation. Volume 26:Number 3(2018)
• Page Start: 425
• Page End: 427
• Publication Date: 2018-04-03
• Subjects: HLA-B27 -- hypopyon -- older -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2016.1234626
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : HLA-B27-associated uveitis is classically thought to be a disease of the young, with a median age of onset in the 30s. There is a paucity of literature reporting on older individuals with HLA-B27 uveitis. Here, we describe cases of HLA-B27 uveitis presenting initially at age ≥70. Methods : Retrospective review of patients with HLA-B27-associated uveitis that presented initially at ≥70 years of age. Results : Three patients were identified. All presented with aggressive inflammation (hypopyon in two cases) and two were treated for suspected endophthalmitis. All cases were controlled sufficiently with prolonged topical anti-inflammatory therapy. One patient who was lost to follow-up demonstrated one recurrence over a 3-year period. Conclusions : This series highlights the aggressive initial presentation of HLA-B27-associated uveitis in the older population, and demonstrates the favorable response, and limitation of recurrences, with topical immunosuppressive therapy.