Axial modification inhibited H-aggregation of phthalocyanines in polymeric micelles for enhanced PDT efficacy. Issue 32 (3rd April 2018) - Jing, Chen
Abstract : How axial and non-axial modified phthalocyanines aggregate into micelles and their performance in terms of PDT efficiency were investigated. Abstract : Axial modified phthalocyanine (BtPc), aiming at avoiding H-aggregation and utilizing long wavelength light, was designed and synthesized. With the aid of polymer nanotechnology, BtPc loaded polymeric micelles with strong singlet oxygen generating ability and enhanced photodynamic therapy efficiency were developed. Optical characterizations and in vitro evaluations proved that the BtPc loaded polymeric micelles hold great potential for photodynamic therapy.