A new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions. Issue 32 (3rd April 2018)

• Record Type: Journal Article
• Authors: Zhao, Yin-Na; Luo, Yong-Chun; Wang, Zhu-Yin; Xu, Peng-Fei
• Is Part Of: Chemical communications. Volume 54:Issue 32(2018)
• Page Start: 3993
• Page End: 3996
• Publication Date: 2018-04-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc01486h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A para -quinone methide and difluoroalkylating reagent involved radical cross-coupling reaction was described, through photocatalytically generated diarylmethane radical intermediates. Abstract : Difluoroalkylated diarylmethanes with biological and pharmacological potentials were synthesized from para -quinone methides ( p -QMs) and difluoroalkylating reagents via a visible light photocatalysis strategy. Mechanism studies showed that the excited photocatalyst, * fac -Ir(ppy)3, was primarily quenched by p -QMs and the generated diarylmethane radical intermediates then underwent a radical–radical cross-coupling reaction with difluoroalkyl radicals. This reaction features mild conditions, high efficiency and wide functional group compatibility.