Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2, 4-diones. (29th March 2018)

• Record Type: Journal Article
• Authors: Rupanwar, Bapurao D.; Chavan, Santosh S.; Shelke, Anil M.; Suryavanshi, Gurunath M.
• Is Part Of: New journal of chemistry. Volume 42:Number 8(2018)
• Page Start: 6433
• Page End: 6440
• Publication Date: 2018-03-29
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj05169g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A TfOH-catalyzed highly efficient synthesis of biologically active ( E )-2-cyanoacrylamides and 3-substituted azetidine-2, 4-diones has been reported with 64–94% yields under metal-free conditions. Abstract : A TfOH-catalyzed highly efficient synthesis of biologically active ( E )-2-cyanoacrylamides and 3-substituted azetidine-2, 4-diones has been reported with 64–94% yields under metal-free conditions. The reaction proceeds through sequential Knoevenagel condensation/stereoselective in situ monohydration of nitrile or C–N cyclization protocol in one-pot. The attractive features of this tandem process are moderate reaction conditions, high atom economy, broad substrate scope, gram-scale reaction and ease of operation.