Glucose-responsive hydrogel electrode for biocompatible glucose transistor. Issue 1 (1st January 2017)

• Record Type: Journal Article
• Authors: Kajisa, Taira; Sakata, Toshiya
• Is Part Of: Science and technology of advanced materials. Volume 18:Issue 1(2017)
• Page Start: 26
• Page End: 33
• Publication Date: 2017-01-01
• Subjects: Field effect transistor -- hydrogel -- phenylboronic acid -- glucose -- biocompatibility; 30 Bio-inspired and -- biomedical materials -- 208 Sensors and actuators -- 600 Others; Materials -- Technological innovations -- Periodicals; 620.112
• DOI: 10.1080/14686996.2016.1257344
• Languages: English
• ISSNs: 1468-6996

Abstract

Abstract: In this paper, we propose a highly sensitive and biocompatible glucose sensor using a semiconductor-based field effect transistor (FET) with a functionalized hydrogel. The principle of the FET device contributes to the easy detection of ionic charges with high sensitivity, and the hydrogel coated on the electrode enables the specific detection of glucose with biocompatibility. The copolymerized hydrogel on the Au gate electrode of the FET device is optimized by controlling the mixture ratio of biocompatible 2-hydroxyethylmethacrylate (HEMA) as the main monomer and vinylphenylboronic acid (VPBA) as a glucose-responsive monomer. The gate surface potential of the hydrogel FETs shifts in the negative direction with increasing glucose concentration from 10 μM to 40 mM, which results from the increase in the negative charges on the basis of the diol-binding of PBA derivatives with glucose molecules in the hydrogel. Moreover, the hydrogel coated on the gate suppresses the signal noise caused by the nonspecific adsorption of proteins such as albumin. The hydrogel FET can serve as a highly sensitive and biocompatible glucose sensor in in vivo or ex vivo applications such as eye contact lenses and sheets adhering to the skin. Abstract :