Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study. Issue 2 (3rd April 2018)

• Record Type: Journal Article
• Authors: Pekcanlar Akay, Aynur; Eresen Yazıcıoğlu, Çiğdem; Alşen Güney, Sevay; Özek Erkuran, Handan; Kızıldağ, Sefa; Baykara, Burak; Özyurt, Gonca; Yıldırımcan Kadıçeşme, Şebnem; Miral, Süha; İnal Emiroğlu, Neslihan
• Is Part Of: Psychiatry and clinical psychopharmacology. Volume 28:Issue 2(2018)
• Page Start: 177
• Page End: 184
• Publication Date: 2018-04-03
• Subjects: Attention deficit/hyperactivity disorder -- adolescents -- catechol-O-methyltransferase gene (COMT) -- dopamine D4 receptor gene (DRD4) -- methylphenidate -- clinical global impression (CGI); Psychopharmacology -- Periodicals; Psychiatry -- Periodicals; Psychiatry; Psychopharmacology; Periodicals; Periodicals; 616
• DOI: 10.1080/24750573.2017.1418134
• Languages: English
• ISSNs: 2475-0573

Abstract

ABSTRACT: OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor ( DRD4 ), and Val158Met polymorphism of catechol-O-methyltransferase ( COMT ) genes. METHODS: Thirty-four adolescents (age range, 13–18 years) with ADHD participated in this study. Thirty-two patients were males and two were females. Du Paul ADHD Rating Scale-Clinician version (ARS) and Clinical Global Impression-severity of impairment (CGI-S) were used for the evaluation of symptom severity. Fifty healthy age-matched adolescents were recruited as controls. RESULTS: When the groups with ( n = 9) and without ( n = 25) 7-repeat alleles for DRD4 were considered, there was a statistically significant decrease of DuPaul ARS total and hyperactivity scores in those treated with OROS-methylphenidate. When the Val/Met allele-positive group for COMT gene ( n = 17) was compared with the Val/Val allele-positive group ( n = 13) and Met/Met allele-positive group ( n = 4), there was a statistically significant decrease of ARS total scores, ARS attention scores, and CGI scores in adolescents with ADHD treated with OROS-MPH. CONCLUSIONS: Specific data from further studies with a larger sample sizes would provide more insights to replicate the current findings.