A highly diastereoselective [3+3] annulation reaction of aza-oxyallyl cations and nitrones. Issue 20 (16th May 2018)

• Record Type: Journal Article
• Authors: Chen, Rongxing; Sun, Shaofa; Wang, Gangqiang; Guo, Haibin
• Is Part Of: Tetrahedron letters. Volume 59:Issue 20(2018)
• Page Start: 1916
• Page End: 1920
• Publication Date: 2018-05-16
• Subjects: [3+3] Annulation -- Aza-oxyallyl cations -- Nitrones -- Metal-free; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.03.085
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Excellent diastereo-control. Broad substrate scope. High chemical yield. Abstract: An efficient synthesis of 1, 2, 4-oxadiazinan-5-ones via [3+3] cycloaddition of in situ generated aza-oxyallyl cations with nitrones has been developed. The protocol features easy operation, excellent yields, excellent diastereo-control, broad substrate scope and good functional group tolerance.