Synthesis of β-heteroaryl carbonyl compounds via direct cross-coupling of allyl alcohols with heteroaryl boronic acids under cooperative bimetallic catalysis. Issue 14 (4th April 2018)

• Record Type: Journal Article
• Authors: Zhu, Mingxiang; Du, Hongli; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie
• Is Part Of: Tetrahedron letters. Volume 59:Issue 14(2018)
• Page Start: 1352
• Page End: 1355
• Publication Date: 2018-04-04
• Subjects: β-Heteroaryl carbonyl compounds -- Allyl alcohols -- Heteroaryl boronic acids -- Photocatalysis reaction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.02.021
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A facile and efficient strategy for the construction of β-heteroaryl carbonyl derivatives has been developed. A broad range of β-heteroaryl carbonyl derivatives can be prepared from heteroaryl boronic acids and allyl alcohols. An eco-friendly cooperative Cu/Pd-catalyzed oxidative Heck reaction was described. Abstract: The eco-friendly cooperative Cu/Pd-catalyzed oxidative Heck reaction of allyl alcohols with heteroaryl boronic acids under air was described. The ready availability of starting materials and the mild reaction conditions made this protocol a safe and operationally convenient strategy for the efficient synthesis of β-heteroaryl carbonyl compounds.