Immunohistochemical Analysis of Prognostic Protein Markers for Primary Localized Clear Cell Renal Cell Carcinoma. (25th January 2013)

• Record Type: Journal Article
• Authors: Weber, Thomas; Meinhardt, Matthias; Zastrow, Stefan; Wienke, Andreas; Fuessel, Susanne; Wirth, Manfred P.
• Is Part Of: Cancer investigation. Volume 31:Number 1(2013)
• Page Start: 51
• Page End: 59
• Publication Date: 2013-01-25
• Subjects: Clear cell renal cell carcinoma -- Localized -- Survivin -- p21 -- Ki67 -- Prognosis; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2012.749267
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract : Recurrence is not reliably predictable in localized clear cell renal cell carcinoma. Proteinmarkers could improve predictive accuracy. Tissue-microarrays from 132 patients with primary localized ccRCC were immunohistochemically analyzed for VHL, Ki67, p53, p21, survivin, and, for microvessel-density, UEA-1. Nuclear stainings of Ki67, p21, and survivin were significantly associated with disease-specific survival and increased predictive ability from 74% to 76%, 77%, and 78%, respectively in a multivariate model including T-stage and Fuhrman grade. A score-variable, combining Ki67-, p21-, and nS-staining identified a subset of patients with high risk of disease recurrence and increased predictive ability in the multivariate model to 84%.