Primary Cutaneous Marginal IgG4 Lymphoma and Rosai–Dorfman's Disease Coexisting in Several Lesions of the Same Patient. (May 2015)

• Record Type: Journal Article
• Authors: Machan, Salma; Medina, Camino; Rodríguez-Pinilla, Socorro María; Suárez-Peñaranda, José M.; Castro, Yolanda; Molés, Paula; Requena, Celia; Saus, Carles; Requena, Luis; Santonja, Carlos
• Is Part Of: American journal of dermatopathology. Volume 37:Number 5(2015)
• Publication Date: 2015-05
• Subjects: primary cutaneous marginal lymphoma -- Rosai–Dorfman disease -- IgG4-related disease; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000000249
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: We report the unique association of primary cutaneous marginal zone B-cell lymphoma and Rosai–Dorfman disease (RDD)–type histiocytic infiltrates involving the same lesions. The patient was an 82-year-old woman with 3 long-standing, well-circumscribed firm erythematous to brownish plaques on her left arm, right scapular area, and lumbosacral area. Histopathologic examination disclosed a dermal and subcutaneous nodular lymphoplasmacytic infiltrate with evidence of germinal center colonization and light-chain restriction and sheets of S-100 CD68-positive histiocytes with ample pale cytoplasm and occasional emperipolesis of lymphocytes. The neoplastic plasma cells expressed immunoglobulin (Ig) G4. A review of 14 examples of cutaneous RDD showed a substantial number of IgG4-positive cells in only 3 of them, and a review of 8 primary cutaneous marginal zone B-cell lymphomas disclosed only 2 with significant IgG4 expression. The coexistence of lymphomas and RDD has been rarely reported in the literature but only seldom involving the same lymph node and—to the best of our knowledge—never in the skin.