Acquisition of CD30 and CD15 Accompanied With Simultaneous Loss of All Pan-T-Cell Antigens in a Case of Histological Transformation of Mycosis Fungoides With Involvement of Regional Lymph Node: An Immunophenotypic Alteration Resembling Classical Hodgkin Lymphoma. (March 2015)

• Record Type: Journal Article
• Authors: Reddi, Deepti M.; Sebastian, Siby; Wang, Endi
• Is Part Of: American journal of dermatopathology. Volume 37:Number 3(2015)
• Publication Date: 2015-03
• Subjects: mycosis fungoides -- histological transformation -- large cell -- CD30 -- CD15; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0b013e31828cf3d3
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: Acquired expression of CD30 is frequently noted in histological transformation of mycosis fungoides (MF), but simultaneous gain of CD15 accompanied with loss of pan-T-cell antigens are extremely rare. We report an unusual case of transformed MF with such an immunophenotypic alteration resembling classical Hodgkin lymphoma. The patient was an 81-year-old male with MF, who was initially treated with topical steroids and phototherapy. Despite the initial response, the patient developed a tumor-like skin lesion that was confirmed to be CD30-positive large T-cell lymphoma and was subsequently found to have a regional lymph node involvement by pleomorphic large cell lymphoma. Besides CD30, pleomorphic large cells were positive for CD15 but negative for all B cell– and T cell–specific antigens. Epstein–Barr virus was negative. Polymerase chain reaction–based assays demonstrated a clonal rearrangement of T-cell receptor gamma gene but detected no B-cell clone. The mechanism and clinical significance of this phenotypic conversion remains to be elucidated.