Combined adenocarcinoma–atypical carcinoid of the lung. Targeted Next-Generation Sequencing (NGS) suggests a monoclonal origin of the two components. Issue 3 (March 2018)

• Record Type: Journal Article
• Authors: La Rosa, Stefano; Simbolo, Michele; Franzi, Francesca; Uccella, Silvia; Imperatori, Andrea; Nardecchia, Elisa; Rotolo, Nicola; Dominioni, Lorenzo; Scarpa, Aldo; Sessa, Fausto
• Is Part Of: Diagnostic histopathology. Volume 24:Issue 3(2018)
• Page Start: 120
• Page End: 123
• Publication Date: 2018-03
• Subjects: adenocarcinoma -- carcinoid -- combined neoplasm -- lung -- mixed neoplasm -- monoclonality; Histology, Pathological -- Periodicals; Cytodiagnosis -- Periodicals; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; Histopathologie -- Périodiques; Pathologie -- Périodiques; Cytodiagnostics -- Périodiques; Diagnostics biologiques -- Périodiques; Histologie -- Technique -- Périodiques; Electronic journals; 616.07582
• DOI: 10.1016/j.mpdhp.2018.02.002
• Languages: English
• ISSNs: 1756-2317

Abstract

Abstract: Combined neoplasms of the lung are defined by the WHO classification as an admixture of a small or large cell neuroendocrine carcinoma and a non-neuroendocrine component. However, rare cases of carcinoids combined with a non-neuroendocrine component have been described. These tumor types are not included as a specific entity in the WHO classification of pulmonary neoplasms and their pathogenesis is still unknown. We describe the clinico-pathologic and molecular features of a mixed (combined) lung neoplasm composed of adenocarcinoma and atypical carcinoid. The NGS analysis of the two different tumor components shows a similar molecular profile suggesting their monoclonal origin from a transformed stem/progenitor tumor cell which acquires a divergent differentiation during its development and progression. We also suggest the use of the recently proposed term of mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) to define mixed (combined) neoplasms of the lung, because it seems to better cover the wide spectrum of different possible combinations of neuroendocrine and non-neuroendocrine components.