Buthus lienhardi venom and pathophysiological effects at the histological, hematological, biochemical and motor skills levels. (May 2018)

• Record Type: Journal Article
• Authors: Ait Laaradia, Mehdi; El Hidan, Moulay Abdelmonaim; Marhoume, Fatimazahra; Bouimeja, Btissam; Oufquir, Sara; Sokar, Zahra; Boumezzough, Ali; Chait, Abderrahman
• Is Part Of: Toxicon. Volume 146(2018)
• Page Start: 106
• Page End: 113
• Publication Date: 2018-05
• Subjects: Buthus lienhardi -- Biochemical -- Hematological -- Histopathology -- Motor system -- Scorpion venom; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2018.03.001
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: The present study investigated the toxic effects of B. lienhardi venom, at the histological, hematological, biochemical and motor skill levels following a subcutaneous injection of different doses of venom. The LD50 of B. lienhardi scorpion venom was found to be 0.27 mg/Kg by subcutaneous injection route. The results clearly indicate that B. lienhardi venom induces massive tissue damages in the organs, such as lungs, heart, kidneys and liver together with hematological impairments manifested by decreased levels of both red and white series. We further demonstrated that scorpion venom is able to alter motor system by inducing motor incoordination and reducing muscle strength. The overall results confirm that the venom from B. lienhardi primarily is a highly toxic agent and has cardiotoxic, nephrotoxic, hepatotoxic and pneumotoxic activity. Highlights: The LD50 of Buthus lienhardi scorpion venom was found to be 0.27 mg/kg by subcutaneous injection route. B. lienhardi venom induces histopathological impairment in pivotal organs. B. lienhardi venom induces a significant rise in the enzymatic functional markers of tissues alteration. B. lienhardi produces hematological changes manifested by decreased levels of both red and white series. B. lienhardi venom induces alteration in motor coordination.