In vivo toxicity studies of fusarium mycotoxins in the last decade: A review. (April 2015)

• Record Type: Journal Article
• Authors: Escrivá, L.; Font, G.; Manyes, L.
• Is Part Of: Food and chemical toxicology. Volume 78(2015)
• Page Start: 185
• Page End: 206
• Publication Date: 2015-04
• Subjects: ADME absorption, distribution, metabolism and excretion -- AFs aflatoxins -- ALT alanine aminotransferase -- HFB1 aminopentol -- AS aluminosilicate -- AST aspartate aminotransferase -- AUC area under curve -- BEA beauvericin -- bw body weight -- CAT catalase -- CYP cytochrome P-450 -- D3G deoxynivalenol-3-β-D-glucoside -- DES diethylstilbestrol -- DNA deoxyribonucleic acid -- DOM-1 deepoxy-deoxynivalenol -- DON deoxynivalenol -- DONS deoxynivalenol sulfonate -- DON-3-GlcA deoxynivalenol-3-glucuronide -- DON-15-GlcA deoxynivalenol-15-GlcA -- EFSA European Food Safety Authority -- ENNs enniatins -- ENN A enniatin A -- ENN B enniatin B -- EPT 12, 13 epoxytrichothec-9-ene -- EU European Union -- FAO Food and Agricultural Organization of the United Nations -- FBs fumonisins B -- FB1 fumonisin B1 -- FUS fusaproliferin -- GMA glucomannan mycotoxin binder -- GPX glutathione peroxidase -- GR glutathione reductase -- GSH glutathione -- HDL high density lipoprotein -- HT2 HT-2 toxin -- HT29 human tissue colon cell line -- IARC International Agency for Research on Cancer -- IP intraperitoneal -- IV intravenous -- LD50 lethal dose 50% -- LDL light density lipoprotein -- LOQ limit of quantification -- LPS lipopolysaccharides -- MAPKs mitogen-activated protein kinases -- MDA malondialdehyde -- MON moniliformin -- mRNA messenger ribonucleic acid -- NIV nivalenol -- NOAEL no-observed-adverse-effect level -- PMTDI provisional maximum tolerable daily intake -- OECD Organisation for Economic Co-operation and Development -- PBMC peripheral blood mononuclear cells -- OTA ochratoxin A -- PBMC peripheral blood mononuclear cells -- PHFB1 partially hydrolyzed fumonisin B1 -- PUBMED Publications of Medicine -- Sa sphinganine -- Sa 1-P sphinganine 1-phosphate -- SBS sodium metabisulfite -- SC subcutaneous -- Se-GSH-Px selenium dependent glutathione peroxidase -- So sphingosine -- So 1-P sphingosine 1-phosphate -- SOD superoxide dismutase -- T2 T2 toxin -- TNF tumor necrosis factor -- WHO World Health Organization -- WOS Web of Science -- ZEA zearalenone -- ZOL zearalenol; Fusarium mycotoxins -- Trichothecenes -- Zearalenone -- Fumonisins -- Emerging mycotoxins -- In vivo assays; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2015.02.005
• Languages: English
• ISSNs: 0278-6915

Abstract

Highlights: A compilation of in vivo studies about Fusarium mycotoxins in the last decade was performed. The main Fusarium mycotoxins studied were identified. The in vivo assays were classified regarding the proposed objective. Aspects such as animal species, doses, application routine, exposure time, and results obtained were analyzed. Abstract: This review summarizes the information regarding the in vivo studies of Fusarium mycotoxins in the last decade. The most common studies are classified as subacute toxicity, subchronic toxicity, acute toxicity, toxicokinetic studies and teratogenicity in order of importance. The most used animals in in vivo studies are pigs, rats, chickens and mice. Fumonisin B1, deoxynivalenol, zearalenone, nivalenol and T-2 toxin are the most studied fusarotoxins. Studies with combinations of mycotoxins are also frequent, deoxynivalenol generally being one of them. The predominant route of administration is oral, administered mostly in the form of naturally contaminated feed. Other administration routes also used are intraperitoneal, intravenous and subcutaneous. In vivo research on Fusarium mycotoxins has increased since 2010 highlighting the need for such studies in the field of food and feed safety.