Identical lesion morphology in primary progressive and relapsing–remitting MS –an ultrahigh field MRI study. (December 2014)

• Record Type: Journal Article
• Authors: Kuchling, Joseph; Ramien, Caren; Bozin, Ivan; Dörr, Jan; Harms, Lutz; Rosche, Berit; Niendorf, Thoralf; Paul, Friedemann; Sinnecker, Tim; Wuerfel, Jens
• Is Part Of: Multiple sclerosis. Volume 20:Number 14(2014)
• Page Start: 1866
• Page End: 1871
• Publication Date: 2014-12
• Subjects: MRI -- primary progressive multiple sclerosis -- PPMS -- relapsing–remitting multiple sclerosis -- RRMS -- ultrahigh field MRI -- 7 T MRI; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458514531084
• Languages: English
• ISSNs: 1352-4585

Abstract

Potential differences between primary progressive (PP) and relapsing–remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.