Early haemoperfusion with continuous venovenous haemofiltration improves survival of acute paraquat-poisoned patients. (February 2015)

• Record Type: Journal Article
• Authors: Gao, Yanxia; Zhang, Xiaofan; Yang, Yanjie; Li, Wenlu
• Is Part Of: Journal of international medical research. Volume 43:Number 1(2015:Feb.)
• Page Start: 26
• Page End: 32
• Publication Date: 2015-02
• Subjects: Continuous venovenous haemofiltration -- haemoperfusion -- paraquat poisoning; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060514549782
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To determine whether haemoperfusion (HP) with continuous venovenous haemofiltration (CVVH) improves the survival of patients with acute paraquat poisoning, compared with those treated using HP alone. Methods: Medical records of patients with acute paraquat poisoning were analysed. Patients were randomised to undergo HP or HP + CVVH within 24 h of paraquat ingestion. Mortality rate, survival duration and cause of death were recorded. Results: There were no significant differences in mortality rate between the HP group ( n = 458) and the HP + CVVH group ( n = 226) (57.4% and 58.4%, respectively). The mean survival duration was significantly longer in the HP + CVVH group than the HP group (8.6 ± 3.1 and 5.1 ± 2.3 days, respectively). Early circulatory collapse was a major cause of death in the HP group. The major cause of death in the HP + CVVH group was late respiratory failure. Conclusion: Combined therapy with HP and CVVH can prevent early death and prolong survival duration following acute paraquat poisoning, providing the opportunity for further treatment.