Obesity and Vitamin D Deficiency: Trends to Promote a More Proatherogenic Cardiometabolic Risk Profile. (March 2015)

• Record Type: Journal Article
• Authors: Stokić, Edita; Kupusinac, Aleksandar; Tomić-Naglić, Dragana; Zavišić, Branka Kovačev; Mitrović, Milena; Smiljenić, Dragana; Soskić, Sanja; Isenović, Esma
• Is Part Of: Angiology. Volume 66:Number 3(2015)
• Page Start: 237
• Page End: 243
• Publication Date: 2015-03
• Subjects: vitamin D deficiency -- obesity -- cardiometabolic risk; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319714528569
• Languages: English
• ISSNs: 0003-3197

Abstract

Vitamin D deficiency is associated with cardiometabolic risk factors (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese patients (body mass index [BMI]: 43.5 ± 9.2 kg/m 2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m 2 ). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25(OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D levels were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L; P < .001). There was a negative correlation between vitamin D level and anthropometric indicators of obesity: BMI ( r = −0.64; P < .001), waist circumference ( r = −0.59; P < .001), and body fat percentage ( r = −0.64; P < .001) as well as with fasting plasma insulin ( r = −0.35; P < .001) and homeostasis model assessment of insulin resistance ( r = −0.35; P < .001). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile.