Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems. Issue 23 (9th April 2018)

• Record Type: Journal Article
• Authors: Hobson, James J.; Edwards, Stephanie; Slater, Rebecca. A.; Martin, Philip; Owen, Andrew; Rannard, Steve P.
• Is Part Of: RSC advances. Volume 8:Issue 23(2018)
• Page Start: 12984
• Page End: 12991
• Publication Date: 2018-04-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra01944d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Branched copolymers offer very efficient nanoemulsion stabilisers with benefits for oral drug delivery. Abstract : The delivery of drugs to the bloodstream via oral administration may suffer from a number of complications including poor dissolution, first pass metabolism and the active intervention of efflux transporters such as P-glycoproteins; drugs which are efflux substrates may cause considerable problems across many clinical conditions. Here we have employed a branch-polymer stabilised nanoemulsion strategy to create highly robust oil droplets ( e.g. peanut oil, castor oil and soybean oil) containing different dissolved antiretroviral drugs used in the daily fight against HIV/AIDS. Although very limited difference in permeation through a Caco-2 gut epithelium model was seen for efavirenz, the permeation of the protease inhibitor lopinavir was considerably higher (approximately 10-fold) when applied to an epithelium monolayer in emulsion form than the control within an aqueous DMSO vehicle. The presented nanoemulsion approach may allow drug-specific permeation improvements for various drug substances.