Synthesis of novel series of 7, 7′-(substituted methylene)bis-imidazo[1, 2-b]pyrazoles via an acid catalyzed one-pot three-component reaction. (15th March 2018)

• Record Type: Journal Article
• Authors: Driowya, Mohsine; Allouchi, Hassan; Gally, José Manuel; Bonnet, Pascal; Guillaumet, Gérald
• Is Part Of: New journal of chemistry. Volume 42:Number 8(2018)
• Page Start: 5728
• Page End: 5741
• Publication Date: 2018-03-15
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj05088g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient and rapid synthesis of new series of N -alkyl-2-aryl-5 H -imidazo[1, 2- b ]pyrazoles has been achieved in high yields through a three-component reaction of 3-amino-4-substituted pyrazoles, aromatic aldehydes and isocyanides mediated by acid catalysts. Abstract : An efficient and rapid synthesis of new series of N -alkyl-2-aryl-5 H -imidazo[1, 2- b ]pyrazoles has been achieved in high yields through a three-component reaction of 3-amino-4-substituted pyrazoles, aromatic aldehydes and isocyanides mediated by acid catalysts. In addition, a novel and straightforward approach to a sequential one-pot multicomponent reaction has been developed for the synthesis of hitherto undescribed 7, 7′-(substituted methylene)bis-imidazo[1, 2- b ]pyrazoles, starting from 3-amino-5-substituted (or unsubstituted) pyrazoles, various aldehydes and isocyanides. The reaction was performed under mild conditions in the presence of inexpensive zirconium(iv ) chloride as a catalyst. A library of 22 products was obtained in moderate to good yields.