DNA nanoclew templated spherical nucleic acids for siRNA delivery. Issue 29 (23rd March 2018)

• Record Type: Journal Article
• Authors: Ruan, Weimin; Zheng, Meng; An, Yang; Liu, Yuanyuan; Lovejoy, David B.; Hao, Mingcong; Zou, Yan; Lee, Albert; Yang, Shu; Lu, Yiqing; Morsch, Marco; Chung, Roger; Shi, Bingyang
• Is Part Of: Chemical communications. Volume 54:Issue 29(2018)
• Page Start: 3609
• Page End: 3612
• Publication Date: 2018-03-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc09257a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed DNA nanoclew (DC). Abstract : A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed a DNA nanoclew (DC). After uptake by cultured cancer cells, SNA nanoparticles release engrafted siRNAs by cleavage of the intracellular Dicer enzyme. Moreover, in vitro experiments reveal that such SNAs demonstrate potent gene knockdown at both mRNA and protein levels, while with negligible cytotoxicity.