The active role of Ca2+ ions in Aβ-mediated membrane damage. Issue 29 (26th March 2018)
- Record Type:
- Journal Article
- Title:
- The active role of Ca2+ ions in Aβ-mediated membrane damage. Issue 29 (26th March 2018)
- Main Title:
- The active role of Ca2+ ions in Aβ-mediated membrane damage
- Authors:
- Sciacca, Michele F. M.
Monaco, Irene
La Rosa, Carmelo
Milardi, Danilo - Abstract:
- Abstract : Calcium ions inhibits Aβ induced membrane poration by small-sized oligomers but significantly foster fiber-dependent membrane disruption. Abstract : Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca 2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.
- Is Part Of:
- Chemical communications. Volume 54:Issue 29(2018)
- Journal:
- Chemical communications
- Issue:
- Volume 54:Issue 29(2018)
- Issue Display:
- Volume 54, Issue 29 (2018)
- Year:
- 2018
- Volume:
- 54
- Issue:
- 29
- Issue Sort Value:
- 2018-0054-0029-0000
- Page Start:
- 3629
- Page End:
- 3631
- Publication Date:
- 2018-03-26
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8cc01132j ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 6226.xml