Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. (May 2018)

• Record Type: Journal Article
• Authors: Jun, Ji Eun; Lee, You-Bin; Lee, Seung-Eun; Ahn, Ji Yeon; Kim, Gyuri; Jin, Sang-Man; Hur, Kyu Yeon; Lee, Moon-Kyu; Kang, Mi Ra; Kim, Jae Hyeon
• Is Part Of: Atherosclerosis. Volume 272(2018)
• Page Start: 233
• Page End: 239
• Publication Date: 2018-05
• Subjects: Uric acid -- Coronary artery calcification -- Cardiovascular disease; SUA serum uric acid -- CVD cardiovascular disease -- CAC coronary artery calcium -- CT computed tomography -- T2D type 2 diabetes -- eGFR estimated glomerular filtration rate -- BMI body mass index -- BP blood pressure -- TC total cholesterol -- TG triglycerides -- LDL low-density lipoprotein -- HDL high-density lipoprotein -- CRP C-reactive protein -- ROC receiver operating characteristic -- AUC area under the curve; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2018.02.014
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Hyperuricemia was frequently noted in subjects with a high risk of cardiovascular disease (CVD). This study aimed to elucidate whether serum uric acid (SUA) is associated with development of moderate coronary artery calcification in generally healthy adults. Methods: A total of 9297 subjects underwent multidetector CT for the evaluation of CAC at least two times during their annual health examinations. Among them, 4461 participants without CVD history and who had no (scores 0) or minimal CAC (scores 1–10) in their first examination were enrolled. The association between SUA as a continuous and categorical variable and development of moderate coronary artery calcification (CAC score > 100) was assessed by Cox regression analysis. Receiver-operating characteristic (ROC) curves were constructed to investigate the diagnostic efficacy of SUA. Results: During a median follow-up of 4.1 years, 131 incident cases of moderate calcification developed. Baseline SUA concentration was significantly higher in subjects with progression to moderate coronary artery calcification (6.6 ± 1.3 vs . 5.8 ± 1.3 mg/dL, p < 0.001). SUA as a continuous variable (per 1 mg/dL) and divided into quartiles was positively associated with a higher risk of development of moderate calcification after adjustment for conventional CVD risk factors. The addition of SUA to the conventional CVD risk factors improved the predictive power for development of moderate coronary artery calcification. Conclusions: SUA was an independent predictor for development of moderate coronary artery calcification in subjects with no or minimal calcification. Highlights: Elevated serum uric acid level was significantly associated with a higher risk of developing moderate coronary artery calcification. Serum uric acid showed incremental prognostic value for development of moderate coronary artery calcification when added to conventional cardiovascular disease risk factors. Serum uric acid might be a potentially useful monitoring tool for detecting subclinical atherosclerosis.