Changes in canine cerebral perfusion after accelerated high frequency repetitive transcranial magnetic stimulation (HF-rTMS): A proof of concept study. (April 2018)

• Record Type: Journal Article
• Authors: Dockx, R.; Baeken, C.; Duprat, R.; De Vos, F.; Saunders, J.H.; Polis, I.; Audenaert, K.; Peremans, K.
• Is Part Of: Veterinary journal. Volume 234(2018)
• Page Start: 66
• Page End: 71
• Publication Date: 2018-04
• Subjects: Canine -- Frontal cortex -- High frequency repetitive transcranial magnetic stimulation -- Regional cerebral blood flow; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2018.02.004
• Languages: English
• ISSNs: 1090-0233

Abstract

Highlights: Transcranial magnetic stimulation (rTMS) is a non-invasive treatment for some neuropsychiatric disorders in human beings. In view of neurobiological similarities of neuropsychiatric disease between dogs and man, rTMS might also benefit dogs. The effect of accelerated high frequency transcranial magnetic stimulation (aHF-rTMS) on the canine cerebrum was assessed. As observed in human beings, aHF-rTMS applied to the left frontal cortex alters regional perfusion in dogs. aHF-rTMS is a safe, non-invasive and pain-free method of increasing rCBF at stimulation site and in remote areas in dogs. Abstract: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for several neuropsychiatric disorders in human beings, but the neurobiological effects of rTMS in dogs have not been investigated to date. A proof of concept study was designed to evaluate the effect of rTMS on cerebral perfusion, measured with single photon emission computed tomography (SPECT), in dogs. An accelerated high frequency (aHF)-rTMS (20 Hz) protocol was applied to the canine left frontal cortex. To accurately target this area, eight dogs underwent a 3 Tesla magnetic resonance imaging (MRI) scan before stimulation. The left frontal cortex was subjected to five consecutive aHF-rTMS sessions with a figure-of-eight coil designed for human beings at an intensity of 110% of the motor threshold. The dogs underwent 99m Tc-d, 1 hexamethylpropylene amine oxime (HMPAO) SPECT scans 1 week prior to and 1 day after the stimulations. Perfusion indices (PIs) were determined semi-quantitatively; aHF-rTMS resulted in significantly increased PIs in the left frontal cortex and the subcortical region, whereas no significant differences were noted for the other regions. Behaviour was not influenced by the stimulation sessions. As has been observed in human beings, aHF-rTMS applied to the left frontal cortex alters regional cerebral perfusion in dogs.