Effects of propofol versus isoflurane on liver function after open thoracotomy. (March 2015)

• Record Type: Journal Article
• Authors: Dabir, Shideh; Mohammad-Taheri, Zohreh; Parsa, Tahereh; Abbasi-Nazari, Mohammad; Radpay, Badiozaman; Radmand, Golnar
• Is Part Of: Asian cardiovascular & thoracic annals. Volume 23:Number 3(2015)
• Page Start: 292
• Page End: 298
• Publication Date: 2015-03
• Subjects: Anesthetics -- inhalation -- isoflurane -- liver function tests -- postoperative complications -- propofol -- thoracotomy; Heart -- Diseases -- Asia -- Periodicals; Heart -- Diseases -- Pacific Area -- Periodicals; Heart -- Diseases -- Periodicals; Heart -- Surgery -- Asia -- Periodicals; Heart -- Surgery -- Pacific Area -- Periodicals; Heart -- Surgery -- Periodicals; Chest -- Surgery -- Asia -- Periodicals; Chest -- Surgery -- Pacific Area -- Periodicals; Chest -- Surgery -- Periodicals; 617.412
• DOI: 10.1177/0218492314551972
• Languages: English
• ISSNs: 0218-4923

Abstract

Background: Anesthetic agents and type of surgery may contribute to postoperative hepatic injury. Inhalational anesthetics have been associated with hepatic dysfunction after surgery, however, propofol is expected to have a lower potential for postoperative liver injury. This prospective double-blind randomized clinical study was planned to determine whether postoperative liver function differs after anesthesia with isoflurane and total intravenous anesthesia with propofol in patients undergoing a posterolateral thoracotomy. Methods: Eighty-eight patients in American Society of Anesthesiologists physical status 1 or 2, aged 16–60 years, and scheduled for an elective posterolateral thoracotomy, were randomly assigned to an anesthetic protocol: propofol ( n = 44) or isoflurane ( n = 44). Induction of anesthesia was similar in both groups. Serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, and γ-glutamyltransferase were measured before induction of anesthesia and on the first and third days after either propofol or isoflurane anesthesia. Results: Mild changes in postoperative serum levels of liver enzymes were significant within each group but the differences between groups were not significant. Conclusions: Propofol and isoflurane anesthesia have a comparable minor effect on liver function after an elective posterolateral thoracotomy.