Cell cycle regulation of mitochondrial function. (April 2015)

• Record Type: Journal Article
• Authors: Lopez-Mejia, Isabel C; Fajas, Lluis
• Is Part Of: Current opinion in cell biology. Volume 33(2015)
• Page Start: 19
• Page End: 25
• Publication Date: 2015-04
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2014.10.006
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : Specific cellular functions, such as proliferation, survival, growth, or senescence, require a particular adaptive metabolic response, which is fine tuned by members of the cell cycle regulators families. Currently, proteins such as cyclins, CDKs, or E2Fs are being studied in the context of cell proliferation and survival, cell signaling, cell cycle regulation, and cancer. We show in this review that cellular, animal and molecular studies provided enough evidence to prove that these factors play, in addition, crucial roles in the control of mitochondrial function; finally resulting in a dual proliferative and metabolic response.