Combinatorial drug delivery strategy employing nano-curcumin and nano-MiADMSA for the treatment of arsenic intoxication in mouse. (25th April 2018)

• Record Type: Journal Article
• Authors: Kushwaha, Pramod; Yadav, Abhishek; Samim, M.; Flora, S.J.S.
• Is Part Of: Chemico-biological interactions. Volume 286(2018)
• Page Start: 78
• Page End: 87
• Publication Date: 2018-04-25
• Subjects: Nanoencapsulation -- Curcumin -- DMSA monoester -- Arsenic -- Metal toxicity -- Oxidative stress -- Nanotherapy; Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2018.03.006
• Languages: English
• ISSNs: 0009-2797

Abstract

Abstract: Chelation therapy is the mainstream treatment for heavy metal poisoning. Apart from this, therapy using antioxidant/herbal extracts are the other strategies now commonly being tried for the treatment. We have previously reported individual beneficial efficacy of nanoparticle mediated administration of an antioxidant like 'curcumin' and an arsenic chelator 'monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA)' for the treatment of arsenic toxicity compared to bulk drugs. The present paper investigates our hypothesis that a combination drug delivery therapy employing two nanosystems, a chelator and a strong antioxidant, may produce more pronounced therapeutic effects compared to individual effects in the treatment of arsenic toxicity. An in-vivo study was conducted wherein arsenic as sodium arsenite (100 ppm) was administered in drinking water for 5 months to Swiss albino mice. This was followed by a treatment protocol comprising of curcumin encapsulated chitosan nanoparticles ( nano-curcumin, 15 mg/kg, orally for 1 month) either alone or in combination with MiADMSA encapsulated polymeric nanoparticles ( nano-MiADMSA, 50 mg/kg for last 5 days) to evaluate the therapeutic potential of the combination treatment. Our results demonstrated that co-treatment with nano-curcumin and nano-MiADMSA provided beneficial effects in a synergistic way on the adverse changes in oxidative stress parameters and metal status induced by arsenic. Highlights: Arsenic induces oxidative stress in target organs. Combination drug delivery therapy employing two nanosystems were compared. Encapsulated curcumin and MiADMSA nanoparticles provided were evaluated. They provided synergistic therapeutic effects against oxidative stress. Nano-drug delivery systems may be good alternate to conventional drug delivery.