Pilot Study Comparing 2 Oral Rehydration Solutions in Patients With Short Bowel Syndrome Receiving Home Parenteral Nutrition: A Prospective Double‐Blind Randomized Controlled Trial. (29th June 2017)

• Record Type: Journal Article
• Authors: Hurt, Ryan T.; Vallumsetla, Nishanth; Edakkanambeth Varayil, Jithinraj; Bonnes, Sara L.; Nanda, Sanjeev; Nadeau, Joseph; Mundi, Manpreet S.
• Is Part Of: Nutrition in clinical practice. Volume 32:Number 6(2017:Dec.)
• Page Start: 814
• Page End: 819
• Publication Date: 2017-06-29
• Subjects: parenteral nutrition -- short bowel syndrome -- fluid therapy -- rehydration solutions -- dehydration -- water‐electrolyte balance; Nutrition -- Periodicals; Diet therapy -- Periodicals; Artificial feeding -- Periodicals; 615.854
• DOI: 10.1177/0884533617714975
• Languages: English
• ISSNs: 0884-5336

Abstract

Abstract : Background: Short bowel syndrome (SBS) is a common indication for home parenteral nutrition (HPN). Oral rehydration solutions (ORSs) have the ability to supplement or reduce HPN dependence. However, ORSs have suffered from poor taste profiles, making long‐term consumption and compliance unlikely. The goal of the current study was to assess the taste and compliance of 2 ORSs among patients with SBS requiring HPN. Methods: All participants with SBS receiving HPN with anticipated duration >3 months were offered enrollment: 31 participants met inclusion criteria; 3 declined enrollment; and 28 were randomized to receive a modified World Health Organization ORS (group A) or a commercially available ORS (DripDrop; group B). Results: Six participants dropped out shortly after randomization (3 in each group) due to poor taste or intolerance. An additional 3 (1 in group A and 2 in group B) discontinued the ORS before the end of the study at 6 months. At the end of the study, 19 remained. The mean taste rating given by the participants was, on a scale of 1–10, 7.3 ± 1.9 for group A and 7.6 ± 1.6 for group B ( P = .61). The mean number of days that ORSs were consumed each week was 6.0 ± 1.3 for group A and 6.6 ± 1 days for group B ( P = .06). Conclusion: Taste rating was not different for both ORSs; however, a significant number of participants did not complete the study.