Hypothalamic Dysfunction Without Hamartomas Causing Gelastic Seizures in Optic Nerve Hypoplasia. (February 2015)

• Record Type: Journal Article
• Authors: Fink, Cassandra; Borchert, Mark; Simon, Carrie Zaslow; Saper, Clifford
• Is Part Of: Journal of child neurology. Volume 30:Number 2(2015:Feb.)
• Page Start: 233
• Page End: 237
• Publication Date: 2015-02
• Subjects: epilepsy -- hypopituitarism -- ophthalmic condition; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073814527156
• Languages: English
• ISSNs: 0883-0738

Abstract

This report describes gelastic seizures in patients with optic nerve hypoplasia and hypothalamic dysfunction without hypothalamic hamartoma. All participants (n = 4) from the optic nerve hypoplasia registry study at Children's Hospital Los Angeles presenting with gelastic seizures were included. The clinical and pathology characteristics include hypothalamic dysgenesis and dysfunction, but no hamartomas. Optic nerve hypoplasia is the only reported condition with gelastic seizures without hypothalamic hamartomas, suggesting that hypothalamic disorganization alone can cause gelastic seizures.