Significance of IMP3, Nucleophosmin, and Ki-67 Expression in Papillary Thyroid Carcinoma. (February 2015)

• Record Type: Journal Article
• Authors: Yorukoglu, Aygun; Yalcin, Nagihan; Avci, Arzu; Cakalagaoglu, Fulya; Yaylali, Guzin; Akin, Fulya; Haciyanli, Mehmet; Ozden, Akin
• Is Part Of: International journal of surgical pathology. Volume 23:Number 1(2015)
• Page Start: 5
• Page End: 12
• Publication Date: 2015-02
• Subjects: nucleophosmin -- IMP3 -- thyroid -- immunohistochemistry -- papillary carcinoma; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896914554832
• Languages: English
• ISSNs: 1066-8969

Abstract

The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism.