Cordyceps sinensis: Anti-fibrotic and inflammatory effects of a cultured polysaccharide extract. (April 2018)

• Record Type: Journal Article
• Authors: Huang, Danfei; Meran, Soma; Nie, Shao-Ping; Midgley, Adam; Wang, Junqiao; Cui, Steve W.; Xie, Mingyong; Phillips, Glyn O.; Phillips, Aled O.
• Is Part Of: Bioactive carbohydrates and dietary fibre. Volume 14(2018)
• Page Start: 2
• Page End: 8
• Publication Date: 2018-04
• Subjects: Cordyceps sinensis -- Bioactivity -- Polysaccharide -- Fibrosis -- Inflammation -- IL-1β -- TGF-β1; Functional foods -- Periodicals; Fiber in human nutrition -- Periodicals; Carbohydrates -- Periodicals; Glycoproteins -- Periodicals; Functional Food -- Periodicals; Dietary Fiber -- Periodicals; Carbohydrates -- Periodicals; Carbohydrates; Fiber in human nutrition; Functional foods; Glycoproteins; Periodicals; 613.28
• DOI: 10.1016/j.bcdf.2017.07.012
• Languages: English
• ISSNs: 2212-6198

Abstract

Abstract: It has been suggested that the traditional Chinese herbal preparation Cordyceps Sinensis (CS) may have a beneficial effect in renal disease. To satisfy increasing demand, CS derivatives have been produced by aseptic mycelia cultivation. We have demonstrated antifibrotic activity of cultured CS previously. The aim of this study was to examine bioactivity of a polysaccharide isolated from cultured CS with a complicated monosaccharide composition, mainly consisting of Gal, Glc and Man. This polysaccharide antagonised the effect of TGF-β1 in stimulating the expression of collagen in the HK2 renal cell line. This was associated with down regulation of the TGF-β receptor Alk5. In addition the polysaccharide antagonised IL-1β stimulated sICAM-1 dependent adherence of monocytes to a monolayer of HK2 cell. This was associated with increased expression of the primary receptor for hyaluronan CD44, and was abrogated by removal of the cell surface hyaluronan pericellular coat. In summary we describe both anti-fibrotic and anti-inflammatory activity in a polysaccharide isolated from cultured CS. Graphical abstract: