Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides. (February 2018)

• Record Type: Journal Article
• Authors: Phua, Siew Cheng; Nihongaki, Yuta; Inoue, Takanari
• Is Part Of: Current opinion in cell biology. Volume 50(2018)
• Page Start: 72
• Page End: 78
• Publication Date: 2018-02
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2018.01.008
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings which have deepened our understanding of the unique yet dynamic phosphoinositide profile found in the primary cilia.