S7-5. Repetitive transcranial magnetic stimulation (rTMS) modulates resting EEG functional connectivity in patients with treatment-resistant depression. Issue 5 (May 2018) - Kito, Shinsuke
Abstract : Aims: Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulation technique for treating patients with depression who do not respond to medications. However, the effects of rTMS on functional connectivity are still not clear. The aims of this study were to examine changes in resting EEG functional connectivity before and after rTMS treatments. Methods: Resting EEG of patients with treatment-resistant depression was recorded for approximately 5 min twice at baseline and at week 4 respectively. The patients received high-frequency left prefrontal rTMS, 5 days a week, for 4 weeks. To examine changes in resting EEG functional connectivity, the EEG data were analyzed using the functional independent component analysis (fICA) and functional wire connectivity analysis (fWCA) in the standardized low-resolution brain electromagnetic tomography (sLORETA). Results: fICA showed that rTMS enhanced the anti-correlated gamma band activities between the left dorsolateral prefrontal cortex (DLPFC) and precuneus. fWCA revealed that there was significant increased functional connectivity in middle beta band between the left DLPFC and parahippocampal gyrus, and between the subgenual cingulate cortex and parahippocampal gyrus. Conclusion: These findings suggest that rTMS might modulate neural networks between the left DLPFC and posterior cingulate, and between the left DLPFC and limbic regions.