Youth offspring of mothers with posttraumatic stress disorder have altered stress reactivity in response to a laboratory stressor. (March 2015)

• Record Type: Journal Article
• Authors: Danielson, Carla Kmett; Hankin, Benjamin L.; Badanes, Lisa S.
• Is Part Of: Psychoneuroendocrinology. Volume 53(2015:Mar.)
• Page Start: 170
• Page End: 178
• Publication Date: 2015-03
• Subjects: Traumatic stress -- Intergenerational transmission -- Salivary cortisol -- Psychopathology; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2015.01.001
• Languages: English
• ISSNs: 0306-4530

Abstract

Highlights: We examine cortisol reactivity among offspring of mothers with and without PTSD. We measure salivary cortisol across five time-points in response to a lab stressor. Offspring of mothers with PTSD exhibit flat cortisol reactivity to stressor. Offspring of mothers without PTSD display peaked cortisol reactivity. Low cortisol reactivity is implicated in intergenerational risk transmission. Summary: Parental Posttraumatic Stress Disorder (PTSD), particularly maternal PTSD, confers risk for stress-related psychopathology among offspring. Altered hypothalamic–pituitary–adrenal (HPA) axis functioning is one mechanism proposed to explain transmission of this intergenerational risk. Investigation of this mechanism has been largely limited to general stress response (e.g., diurnal cortisol), rather than reactivity in response to an acute stressor. We examined cortisol reactivity in response to a laboratory stressor among offspring of mothers with a lifetime diagnosis of PTSD ( n = 36) and age- and gender- matched control offspring of mothers without PTSD ( n = 36). Youth (67% girls; mean age = 11.4, SD = 2.6) participated in a developmentally sensitive laboratory stressor and had salivary cortisol assessed five times (one pre-stress, one immediate post-stress, and three recovery measures, spaced 15 min apart). Results were consistent with the hypothesis that offspring of mothers with PTSD would exhibit a dysregulated, blunted cortisol reactivity profile, and control offspring would display the expected adaptive peak in cortisol response to challenge profile. Findings were maintained after controlling for youth traumatic event history, physical anxiety symptoms, and depression, as well as maternal depression. This finding contributes to the existing literature indicating that attenuated HPA axis functioning, inclusive of hyposecretion of cortisol in response to acute stress, is robust among youth of mothers with PTSD. Future research is warranted in elucidating cortisol reactivity as a link between maternal PTSD and stress-related psychopathology vulnerability among offspring.