Marital discord, past depression, and metabolic responses to high-fat meals: Interpersonal pathways to obesity. (February 2015)

• Record Type: Journal Article
• Authors: Kiecolt-Glaser, Janice K.; Jaremka, Lisa; Andridge, Rebecca; Peng, Juan; Habash, Diane; Fagundes, Christopher P.; Glaser, Ronald; Malarkey, William B.; Belury, Martha A.
• Is Part Of: Psychoneuroendocrinology. Volume 52(2015:Feb.)
• Page Start: 239
• Page End: 250
• Publication Date: 2015-02
• Subjects: Marriage -- Depression -- Resting energy expenditure -- Triglycerides -- Insulin -- Inflammation; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2014.11.018
• Languages: English
• ISSNs: 0306-4530

Abstract

Highlights: During two 9.5 h visits, 43 healthy married couples received two high-fat meals. Behavioral coding of couples' problem discussions provided data on hostile behavior. Hostile behavior and past depression heighted post-meal insulin. Hostile behavior and past depression slowed post-meal energy expenditure (REE). The joint REE behavior/depression difference translates into128 calories per day. Abstract: Background: Longitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related metabolic responses to high-fat meals. Methods: This double-blind, randomized crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, insulin, glucose, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) before and after two high-fat meals. During two separate 9.5 h visits, 43 healthy married couples, ages 24–61 (mean = 38.22), received either a high saturated fat meal or a high oleic sunflower oil meal, both 930 kcal and 60 g fat. The Structured Diagnostic Interview for DSM-IV assessed mood disorder history. Couples discussed a marital disagreement during both visits; behavioral coding of these interactions provided data on hostile marital behaviors. Results: Men and women who displayed more hostile behaviors and who also had a mood disorder history had significantly lower post-meal REE, higher insulin, and higher peak triglyceride responses than other participants, with nonsignificant effects for fat and carbohydrate oxidation. Participants with a mood disorder history had a steeper rise in postprandial IL-6 and glucose than those without a past history. Higher levels of hostile behaviors were associated with higher post-meal TNF-α. The two meals did not differ on any outcome assessed. Conclusions: People spend about 18 of every 24 h in a postprandial state, and dining with one's partner is a common daily event. Among subjects with a mood disorder history, the cumulative 6.75-h difference between high and low hostile behaviors translates into 128 kcal, a difference that could add 7.6 pounds/year. Our findings illustrate novel pathways through which chronic marital stress and a mood disorder history synergistically heighten the risk for obesity, metabolic syndrome, and cardiovascular disease.