Brain white matter microstructural alterations in children of type I Gaucher disease characterized with diffusion tensor MR imaging. Issue 102 (May 2018)

• Record Type: Journal Article
• Authors: Kang, Huiying; Zhang, Miao; Ouyang, Minhui; Guo, Ruolan; Yu, Qinlin; Peng, Qinmu; Zhang, Ningning; Zhang, Yonghong; Duan, Yanlong; Tang, Xiaolu; Mishra, Virendra; Fang, Fang; Li, Wei; Huang, Hao; Peng, Yun
• Is Part Of: European journal of radiology. Issue 102(2018)
• Page Start: 22
• Page End: 29
• Publication Date: 2018-05
• Subjects: WM white matter -- Type I GD type I Gaucher disease -- TD typical development -- DTI diffusion tensor Imaging -- FA fractional anisotropy -- MD mean diffusivity -- AD Axial diffusivity -- RD radial diffusivity -- GBA beta-glucocerebrosidase -- ERT enzyme replacement therapy -- TBSS tract-based spatial statistics -- IRB institutional review board -- FDR false discovery rate -- CFR crossing-fiber region -- SCP superior cerebellar peduncle -- PLIC-R right posterior limb of internal capsule -- PCR-R right posterior corona radiata -- PTR-R right posterior thalamic radiation -- SCR-R right superior corona radiata -- PCR-R right posterior corona radiata -- PTR-R right posterior thalamic radiation -- SCR-R right superior corona radiata -- MCP middle cerebellar peduncle -- PTR-R right posterior thalamic radiation -- SLF-R right superior longitudinal fasciculus -- ACR-L left anterior corona radiata -- ALIC-R right anterior limb of the internal capsule -- ACR-R right anterior corona radiata -- GCC genu of corpus callosum; Gaucher disease -- Children -- Diffusion tensor imaging -- White matter; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2018.02.014
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: WM microstructural alterations were found in children with type I GD. The disease duration was significantly correlated with the WM microstructural changes. DTI can be used to evaluate brain microstructural alterations in GD. Neurological and cognitive symptoms should be monitored in GD during the follow-up. Abstract: Objectives: To investigate white matter (WM) microstructural alterations in type I Gaucher disease (type I GD) pediatric patients and explore the correlation between the disease duration and WM changes. Methods: Twenty-two GD patients and twenty-two sex- and age-matched typical development (TD) children were recruited. Changes in WM were investigated using diffusion tensor imaging (DTI) and applying atlas-based tract analysis. For all DTI measurements, independent-samples t -test was applied to report significant differences between type I GD and TD. Partial correlation was applied to determine whether the disease duration was correlated with DTI measurements. Results: Bidirectional fractional anisotropy (FA) changes were found in the bilateral superior cerebellar peduncle, right posterior limb of the internal capsule, right posterior corona radiata, and right posterior thalamic radiation (p < 0.05). Higher mean diffusivity (MD)was found in the right superior corona radiata, middle cerebellar peduncle, right posterior thalamic radiation and right superior longitudinal fasciculus (p < 0.05) in type I GD. And higher radial diffusivity (RD) was also found in the left superior cerebellar peduncle (p < 0.05) in type I GD. The disease duration of type I GD patients is positively correlated with axial diffusivity and MD in multiple major WM tracts. Conclusion: DTI findings supported the microstructural alterations of multiple WM tracts in type I GD patients.