Aronia berry (Aronia mitschurinii 'Viking') inhibits colitis in mice and inhibits T cell tumour necrosis factor-α secretion. (May 2018)

• Record Type: Journal Article
• Authors: Martin, Derek A.; Smyth, Joan A.; Liu, Zhenhua; Bolling, Bradley W.
• Is Part Of: Journal of functional foods. Volume 44(2018)
• Page Start: 48
• Page End: 57
• Publication Date: 2018-05
• Subjects: Aronia berry -- Inflammation -- Colitis -- Adoptive transfer -- T cell -- Polyphenol; COX-2 cyclooxygenase-2 -- db-cAMP dibutyryl-cAMP -- DP degree of polymerization -- DPBS Dulbecco's phosphate buffered saline -- DSS dextran sulphate sodium -- ELISA enzyme-linked immunosorbent assay -- FBS fetal bovine serum -- HED human equivalent dose -- HILIC hydrophilic interaction chromatography -- hs-CRP high-sensitivity C-reactive protein -- IBD inflammatory bowel disease -- IFN-γ interferon-γ -- iNOS inducible nitric oxide synthase -- LPS lipopolysaccharide -- MCP-1 monocyte chemotactic protein-1 -- PI phorbol 12-myristate 13-acetate and ionomycin -- PMA phorbol 12-myristate 13-acetate -- RAG1 recombinase activating gene-1; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.02.025
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Aronia berry supplementation increased colonic IL-10 secretion in healthy mice. Aronia berry protected against wasting associated with colitis. Aronia extracts and polyphenols inhibited T cell TNF-α in vitro . Certain polyphenol catabolites were more potent TNF-α inhibitors than anthocyanins. Abstract: Aronia berries are rich in polyphenols with anti-inflammatory activity. We hypothesized that aronia berry consumption modulates intestinal immune function and T cells. The aims of the present work were to assess the immunomodulatory potential of 'Viking' aronia berry (black chokeberry, Aronia mitschurinii ) in vivo and to determine the extent aronia berry polyphenols or known microbial polyphenol catabolites inhibit T cell tumour necrosis factor (TNF)-α in vitro . Aronia berry consumption increased colonic IL-10 secretion in healthy mice, but did not inhibit ex vivo cytokine secretion of lipopolysaccharide-stimulated spleen and colon tissue. Aronia berry consumption inhibited wasting associated with T cell adoptive transfer and dextran sulphate sodium induced colitis. Aronia extracts, neutral phenols fraction, and the polyphenol catabolites 3, 4-dihydroxyphenylacetic acid and 3, 4-dihydroxyphenylpropionic acid inhibited TNF-α production in Jurkat T cells. Therefore, T cells and microbial catabolism partly mediate the anti-inflammatory effects of aronia consumption in the colon.