Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats. (April 2018)

• Record Type: Journal Article
• Authors: Kim, Kyeong Seok; Lim, Hyun-Jung; Lim, Jong Seung; Son, Ji Yeon; Lee, Jaewon; Lee, Byung Mu; Chang, Seung-Cheol; Kim, Hyung Sik
• Is Part Of: Food and chemical toxicology. Volume 114(2018)
• Page Start: 34
• Page End: 40
• Publication Date: 2018-04
• Subjects: Curcumin -- Cadmium -- Renal toxicity -- Urinary biomarker; ALT alanine aminotransferase -- AST aspartate aminotransferase -- BUN blood urea nitrogen -- FBS fetal bovine serum -- GFR glomerular filtration rate -- HRP horseradish peroxidase -- 3-IS 3-indoxyl sulfate -- Kim-1 kidney injury molecule-1 -- LDH lactate dehydrogenase -- NGAL neutrophil gelatinase-associated lipocalin -- OPN osteopontin -- PVDF polyvinylidene difluoride -- SDS sodium dodecyl sulfate -- sCr serum creatinine -- TIMP-1 tissue inhibitor of metalloproteinases 1; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.02.007
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Chronic exposure to cadmium (Cd) causes remarkable damage to the kidneys, a target organ of accumulated Cd after oral administration. The aim of the present study was to investigate the protective effect of curcumin against Cd-induced nephrotoxicity. Sprague–Dawley male rats were divided into the following four treatment groups: control, curcumin (50 mg/kg, oral), CdCl2, (25 mg/kg, oral), and pre-treatment with curcumin (50 mg/kg) 1 h prior to the administration of CdCl2 (25 mg/kg, oral) for 7 days. At 24 h after the final treatment, the animals were killed, and the biomarkers associated with nephrotoxicity were measured. Our data indicated that blood urea nitrogen (BUN) and serum creatinine (sCr) levels were significantly reduced by curcumin pre-treatment in CdCl2 -treated animals. Histopathological studies showed hydropic swelling and hypertrophy of the proximal tubular cells in the renal cortex after Cd treatment. Pretreatment with curcumin ameliorated the histological alterations induced by Cd. The urinary excretion of kidney injury molecule-1 (Kim-1), osteopontin (OPN), tissue inhibitor of metalloproteinases 1 (TIMP-1), neutrophil gelatinase-associated lipocalin (NGAL), and netrin-1 significantly reduced by curcumin treatment compared to that in the CdCl2 -treated group. The administration of curcumin provided a significant protective effect against Cd-induced nephrotoxicity. Highlights: Curcumin protects against cadmium-induced renal injury. Curcumin reduces urinary excretion of AKI biomarkers. Curcumin protects against cadmium-induced apoptosis in the kidney.