Role of Rab GTPases in the export trafficking of G protein-coupled receptors. (4th March 2018)

• Record Type: Journal Article
• Authors: Wang, Guansong; Wei, Zhe; Wu, Guangyu
• Is Part Of: Small GTPases. Volume 9:Number 1/2(2018)
• Page Start: 130
• Page End: 135
• Publication Date: 2018-03-04
• Subjects: cell surface expression -- export trafficking -- G protein-coupled receptor -- post-Golgi traffic -- Rab26 -- Rab8 -- Rab GTPase; Guanosine triphosphatase -- Periodicals; Guanosine triphosphatase; Periodicals; 572.793
• DOI: 10.1080/21541248.2016.1277000
• Languages: English
• ISSNs: 2154-1256

Abstract

ABSTRACT: G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface receptors that regulate a variety of cell functions. As the cell surface is the functional destination for most GPCRs, the cell surface targeting process represents a crucial checkpoint in controlling the functionality of the receptors. However, the molecular mechanisms underlying the cell surface delivery of newly synthesized GPCRs remain poorly understood. In this review, we will highlight the role of Rab GTPases in GPCR cell surface transport, particularly post-Golgi traffic, and discuss the underlying molecular mechanisms.