Copper-catalysed dehydrogenative α-C(sp3)–H amination of tetrahydroquinolines with O-benzoyl hydroxylamines. Issue 4 (26th October 2017)

• Record Type: Journal Article
• Authors: Zhao, He; Chen, Xiuwen; Jiang, Huanfeng; Zhang, Min
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 4(2018)
• Page Start: 539
• Page End: 543
• Publication Date: 2017-10-26
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00794a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A copper-catalysed dehydrogenative α-C(sp 3 )–H amination of tetrahydroquinolines with O -benzoyl hydroxylamines has been demonstrated, which enables direct access to 2-alkylaminoquinolines in efficient manner. Abstract : A copper-catalysed dehydrogenative α-C(sp 3 )–H amination of tetrahydroquinolines with O -benzoyl hydroxylamines has been demonstrated for the first time, which proceeds with the merits of operational simplicity, good functional tolerance, mild conditions, the use of O2 as the oxidant and no need for the installation of directing groups.