Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H. Issue 4 (9th November 2017)

• Record Type: Journal Article
• Authors: Sheng, Jie; Ni, Hui-Qi; Bian, Kang-Jie; Li, Yan; Wang, Yi-Ning; Wang, Xi-Sheng
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 4(2018)
• Page Start: 606
• Page End: 610
• Publication Date: 2017-11-09
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00934h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed with the industrial raw material BrCF2 H. Abstract : A nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed for the first time, demonstrating good efficiency, mild conditions, and good functional-group compatibility. The key to success is the combination of different kinds of readily available nitrogen and phosphine ligands with a nickel source, which can generate a variety of easily tunable catalysts in situ to promote the difluoromethylation of a broad scope of aryl boronic acids.